The number of reported measles cases in the United States hit 465 as of April 4, the U.S. Centers for Disease Control and Prevention said Monday.

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That’s 78 more than in the previous week’s update, CNN reported.

The update said that Florida, Indiana, Massachusetts and Nevada had their first cases of measles this year, bringing the total number of states reporting cases to 19.

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The other states are Arizona, California, Colorado, Connecticut, Georgia, Illinois, Kentucky, Michigan, Missouri, New Hampshire, New Jersey, New York, Oregon, Texas and Washington, CNN reported.

The number of measles cases this year “is the second greatest number of cases reported in the U.S. since measles was eliminated in 2000,” according to the CDC.

Last year’s total was 372 cases. The largest outbreak occurred in 2014, with 667 cases, CNN reported.

Measles is highly contagious, but it can be prevented through vaccination. One reason for the rising number of measles cases is anti-vaccine misinformation being spread by so-called anti-vaxxers, experts say.

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