What is simethicone, and how does it work (mechanism of action)?

Simethicone is an anti-gas (anti-flatulence) medication. It acts in the stomach and intestines to change the surface tension of gas bubbles, enabling their breakdown and the formation of larger bubbles. In this way it is believed that gas can be eliminated more easily by belching or passing flatus. Simethicone was approved by the FDA in 1952.

Is simethicone available as a generic drug?


Do I need a prescription for simethicone?


Which drugs or supplements interact with simethicone?

There are no known drug interactions with simethicone.

Is simethicone safe to take if I’m pregnant or breastfeeding?

Safety during pregnancy has not been adequately evaluated. Simethicone is generally considered safe during pregnancy because it does not cross the placenta.

Simethicone is considered safe during lactation because it is not absorbed into the body and infants are often treated with simethicone.

What else should I know about simethicone?

What preparations of simethicone are available?

Liquid drops: 40 mg per 0.6 ml. Chewable tablets: 40, 80 and 125 mg. Capsules: 125 and 180 mg.

How should I keep simethicone stored?

Preparations should be stored at room temperature, 15 C – 30 C (59 F – 86 F).

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Medically Reviewed on 6/26/2019



FDA Prescribing Information.

Black R, Hill A. Over the counter medications in pregnancy. Am Fam Physician. 2003 Jun 15;67(12):2517-2524.