What is clomiphene, and how does it work (mechanism of action)?

Clomiphene is an oral medication used for stimulating ovulation. It binds to estrogen receptors in the hypothalamus, pituitary gland, ovary, endometrium, vagina, and cervix. It causes production of hormones (gonadotropins) by the pituitary which stimulates ovulation. The FDA approved clomiphene in February 1967.

What brand names are available for clomiphene?


Is clomiphene available as a generic drug?


Do I need a prescription for clomiphene?


What is the dosage for clomiphene?

The recommended dose is 50 to 100 mg orally for 5 days. The initial dose is 50 mg which may be increased to 100 mg if there is no response. Dosage may be repeated as early as 30 days after the previous treatment.

Which drugs or supplements interact with clomiphene?

No drug interactions are listed in the prescribing information.

Is clomiphene safe to take if I’m pregnant or breastfeeding?

Clomiphene should not be taken by pregnant women since it does not offer any benefit to pregnant women.

It is not known whether clomiphene is excreted into breast milk. It may reduce lactation in some women.

What else should I know about clomiphene?

What preparations of clomiphene are available?

Tablets: 50 mg

How should I keep clomiphene stored?

Tablets should be stored at room temperature, 15 C to 30 C (59 F to 86 F).

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Medically Reviewed on 7/9/2019



FDA Prescribing Information