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Prime-boost H7N9 influenza vaccine concept promising in clinical trial

Prime-boost H7N9 influenza vaccine concept promising in clinical trial

In clinical trials, several candidate H7N9 pandemic influenza vaccines made from inactivated viruses have been shown to be safe and to generate an immune response. However, scientists believe for practical use, these potential vaccines would require multiple doses or the addition of adjuvants, which enhance the immune response. With hopes of making one dose of […]

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Avian influenza expert raises concerns as USDA stockpiles vaccines

Avian influenza expert raises concerns as USDA stockpiles vaccines

The U.S. Department of Agriculture is creating a stockpile of avian influenza vaccines, but an expert suggests careful consideration of the strategy and cautions that the strain of the next outbreak is unknown. Wild birds are typically the source of the introduction of the virus to backyard and commercial poultry flocks, which makes it very […]

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Rapidly assessing the next influenza pandemic

Rapidly assessing the next influenza pandemic

Influenza pandemics are potentially the most serious natural catastrophes that affect the human population. New findings published in PLOS Computational Biology suggest that with both timely and accurate data and sophisticated numerical models, the likely impact of a new pandemic can be assessed quickly, and key decisions made about potential mitigation strategies. Novel strains of […]

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Hepatitis A-like virus identified in seals

Hepatitis A-like virus identified in seals

Scientists in the Center for Infection and Immunity at Columbia University’s Mailman School of Public Health have discovered a new virus in seals that is the closest known relative of the human hepatitis A virus. The finding provides new clues on the emergence of hepatitis A. The research appears in the July/August issue of mBio, […]

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Flexible future of point-of-care disease diagnostic

Flexible future of point-of-care disease diagnostic

The world-wide deployment of biomedical devices for health monitoring, point-of-care diagnostics and environmental sensing is hampered by their high cost that is not readily affordable for e.g. developing countries. The primary task is therefore to reduce the price of the devices and allow for their high-volume delivery in a cost efficient manner, e.g. container transportation. […]

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Adjuvants improve immune response to H7N9 flu vaccine

Adjuvants improve immune response to H7N9 flu vaccine

In a phase 2 trial that included nearly 1,000 adults, the AS03 and MF59 adjuvants (a component that improves immune response of inactivated influenza vaccines) increased the immune responses to two doses of an inactivated H7N9 influenza vaccine, with AS03-adjuvanted formulations inducing the highest amount of antibody response, according to a study in JAMA. In […]

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Virus-like particle vaccine protects mice from many flu strains

Virus-like particle vaccine protects mice from many flu strains

NIAID research could aid development of universal flu vaccine A vaccine that protects against a wide variety of influenza viruses (a so-called universal flu vaccine) is a critical public health goal given the significant rates of illness and death caused by seasonal influenza and the potentially devastating effects of a pandemic influenza strain. Now, researchers […]