A “bellwether” trial to determine whether a California man’s cancer was caused by Roundup weed killer is underway in San Francisco.

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Attorneys for Edwin Hardeman, 70, say his case could help determine the fate of hundreds of similar lawsuits involving Monsanto’s weed killer, the Associated Press reported.

The case in federal court began on Monday and will be decided by a jury.

In August, a San Francisco jury in awarded another man $289 million after deciding that Roundup caused his non-Hodgkin’s lymphoma. A judge later cut the award to $78 million, and Monsanto has appealed.

Hardeman’s trial is before a different judge, U.S. Judge Vince Chhabria, who is overseeing hundreds of Roundup lawsuits and considers Hardeman’s case and two others “bellwether trials,” the AP reported.

“If we are able to succeed here then it really sends a signal to Monsanto and specifically to Bayer that they have a real problem,” said Hardeman’s attorney, Brent Wisner.

Thousands of other Roundup lawsuits are pending in state courts nationwide, the AP reported.

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