What is metaxalone, and how does it work (mechanism of action)?

Metaxalone is an oral drug that relaxes skeletal muscle the muscles that control movement of the body. It does not act directly on skeletal muscle, and the exact mechanism of action of metaxalone is unknown. Metaxalone relaxes muscles possibly by affecting the central nervous system (brain and spinal cord) and by causing sedation. Metaxalone was approved by the FDA in 1962.

What brand names are available for metaxalone?


Do I need a prescription for metaxalone?


What are the side effects of metaxalone?

The most common side effects with metaxalone are:

Other important, but less common, side effects include:


What is the dosage for metaxalone?

Metaxalone usually is taken at a dose of 800 mg, three or four times daily. Benefits are seen within one hour of ingestion. Food high in fat content increases the absorption of metaxalone.

Is metaxalone safe to take if I’m pregnant or breastfeeding?

Metaxalone has not been adequately studied in pregnant women.

NURSING MOTHERS: It is not known whether metaxalone is excreted in breast milk. Safety for use in the nursing mother has not been established.

What else should I know about metaxalone?

What preparations of metaxalone are available?

Tablets: 800 mg. STORAGE: Tablets should be stored at room temperature, 15-30 C (59-86 F).

Medically Reviewed on 3/27/2019


Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine


FDA Prescribing Information