Ibuprofen (Advil, Motrin, and many other brand names) and meloxicam (Mobic) belong to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs), and are used to manage mild to moderate pain, inflammation, and fever. NSAIDs block enzymes that make chemicals that contribute to inflammation (prostaglandins), which reduces prostaglandin levels and thus inflammation. Meloxicam is a prescription drug and is stronger than ibuprofen (which is available over-the-counter (OTC) at relieving pain and inflammation.

Common side effects of both ibuprofen and meloxicam include heartburn, constipation, drowsiness, dizziness, abdominal pain, tinnitus, rash, nausea, and diarrhea. Both NSAIDs have serious side effects that include edema, blood clots, heart attacks, high blood pressure, heart failure, and stomach ulcers.

Other side effects of meloxicam include intestinal gas, headache, joint pain, back pain, insomnia, itching, bladder infection, skin rash, and upper respiratory tract infection.

The dosage for ibuprofen is 1 to 2 tablets every 4 to 6 hours. No more than 6 tablets should be taken in 24 hours unless advised by a doctor or other healthcare professional. Meloxicam is only taken once a day. Dosage depends upon the condition being treated.