Which drugs or supplements interact with Harvoni ?

Acid reducing agents which are commonly used to treat heartburn, indigestion, and GERD may decrease the effectiveness of Harvoni treatment by decreasing blood levels of ledipasvir. Examples of acid reducing agents include antacids, histamine 2 receptor antagonists, for example, famotidine (Pepcid), and proton pump inhibitors (PPIs), for example, omeprazole (Prilosec).

Antacid and Harvoni administration should be separated by 4 hours. Doses of histamine 2 receptor antagonists equivalent to famotidine 40 mg twice daily or less and doses of proton pump inhibitors equivalent to 20 mg of omeprazole or lower may be given at the same time as Harvoni.

Co-administration of Harvoni and amiodarone is not recommended because the combination may cause serious heart-related side effects including symptomatic bradycardia.

Anti-seizure medications including carbamazepine (Tegretol), phenytoin (Dilantin), phenobarbital (Luminal), and oxcarbazepine (Trileptal) may increase the breakdown of Harvoni, leading to reduced therapeutic effectiveness.

Taking St. John’s Wort or rifampin with Harvoni may also reduce the effectiveness of treatment and is not recommended.

Certain medication used to treat tuberculosis (TB) infection may decrease the effectiveness of Harvoni treatment. Patients taking rifampin, rifabutin, or rifapentine should consult with their doctor or pharmacist before starting Harvoni.

Co-administration of Harvoni with rosuvastatin (Crestor), a cholesterol lowering medication, may significantly increase the blood concentration of rosuvastatin and increase the risk side effects such as serious muscle injury.

Drug interactions with certain HIV antiretroviral therapies and Harvoni have also been reported. Patients receiving HIV treatment are advised to consult with their doctor or pharmacist before starting Harvoni.

PREGNANCY: Although no fetal adverse events were reported in animal studies, adequate and well-controlled studies of Harvoni treatment in pregnant women are lacking. Therefore, Harvoni should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.

NURSING MOTHERS: It is not known whether Harvoni is excreted into human milk. Due to the lack of conclusive safety data, Harvoni should be used cautiously while breastfeeding.

What else should I know about Harvoni ?

What preparations of Harvoni are available?

Oral tablets containing 90 mg ledipasvir and 400 mg sofosbuvir.

How should I keep Harvoni stored?

Harvoni should be stored in its original container and at room temperature, between 15 C and 30 C (59 F and 86 F).