What is sodium citrate (alk) citric acid? What is it used for?

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Sodium citrate/citric acid is used to make urine less acidic and therefore prevent formation of kidney stones. Sodium citrate/citric acid also is useful as a buffer and neutralizing agent for gastric acid. Sodium citrate is broken down to sodium bicarbonate which decreases the acidity of urine, increasing the excretion of substances that cause kidney stones.

What brand names are available for sodium citrate (alk) citric acid?

Cytra-2

Is sodium citrate (alk) citric acid available as a generic drug?

Yes

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Do I need a prescription for sodium citrate (alk) citric acid?

Yes

What is the dosage for sodium citrate (alk) citric acid?

Systemic alkalization:

  • Adult: Take 2 to 6 teaspoons (10 to 30 ml) of liquid diluted in 1 to 3 ounces (30 to 90 ml) of water after meals and at bedtime, or as directed by doctor.
  • Pediatric: Take 1 to 3 teaspoons (5 to 15 ml) of liquid diluted in 1 to 3 ounces (30 to 90 ml) of water after meals and at bedtime, or as directed by doctor.

Neutralizing buffer: Take 3 teaspoons (15 ml), diluted in 15 ml of water, taken as single dose or as directed by doctor.

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Safe and effective use of sodium citrate/citric acid is not established for children under two years of age.

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Which drugs or supplements interact with sodium citrate (alk) citric acid?

: Sodium citrate/citric reduces stomach acidity, which reduces the absorption and may decrease the effectiveness atazanavir (Reyataz), ritonavir (Norvir), and indinavir (Crixivan), antibiotics like ciprofloxacin (Cipro), moxifloxacin (Avelox), doxycycline (Vibramycin), tetracycline (Tetracon), and antifungals like ketoconazole (Nizoral) and itraconazole (Sporanox).

Sodium citrate/citric acid reduces stomach acidity, which can lead to increased digoxin (Lanoxin) absorption and possible digoxin side effects like dizziness, headache, nausea, diarrhea, irregular heart rate and rhythm, and visual disturbances.

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Is sodium citrate (alk) citric acid safe to take if I’m pregnant or breastfeeding?

It is not known whether sodium citrate/citric acid enters breast milk; therefore, it is best to be cautious before using it in nursing mothers.

What else should I know about sodium citrate (alk) citric acid?

What preparations of sodium citrate (alk) citric acid are available?

Sodium citrate/citric acid oral solution contains 500 mg of sodium citrate dihydrate and 334 mg of citric acid monohydrate per 5 ml, available in 16 fluid ounce bottles. Sodium citrate/citric acid is grape flavored and sugar free liquid.

How should I keep sodium citrate (alk) citric acid stored?

Store sodium citrate/citric acid solution at room temperature between 20 C and 25 C (68 F and 77 F). Keep container tightly closed. Keep from excessive heat or freezing.

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Medically Reviewed on 7/9/2019

References

REFERENCE:

FDA Prescribing Information.