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Tofacitinib citrate (Xeljanz)

What is Tofacitinib citrate (Xeljanz), and how does it work (mechanism of action)? Tofacitinib is an oral drug used for treating rheumatoid arthritis. It belongs to a class of drugs called Janus kinase (JAK) inhibitors. JAKs are enzymes (proteins) that regulate chemical signaling pathways that control biologic processes such as blood formation and the immune […]

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azathioprine (Azasan)

What is azathioprine, and how does it work (mechanism of action)? Azathioprine is an immunosuppressant, that is, a drug that is used to suppress the immune system. It is used to treat patients who have undergone kidney transplantation and for diseases in which modifying the activity of the immune system is important. Azathioprine is a […]

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What to know about psoriatic arthritis mutilans

What to know about psoriatic arthritis mutilans

Arthritis mutilans is a rare and severe form of arthritis that affects the hands and feet. It is most common in people with psoriatic arthritis but can also develop in those with rheumatoid arthritis. Psoriatic arthritis mutilans is very rare. Approximately 5 percent of people with psoriatic arthritis (PsA) develop this condition. Arthritis mutilans can […]

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flurbiprofen (Ansaid)

What is flurbiprofen, and how does it work (mechanism of action)? Flurbiprofen is a nonsteroidal anti-inflammatory drug (NSAID) effective in treating fever, pain, and inflammation in the body. It is similar to ibuprofen (Motrin or Advil), naproxen (Naprosyn), and others. As a group, NSAIDs are non-narcotic relievers of mild to moderate pain of many causes, […]

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What to know about psoriatic arthritis jaw pain

What to know about psoriatic arthritis jaw pain

Psoriatic arthritis can affect any joint in the body, including the jaw. The condition can cause jaw pain, teeth grinding, and other dental issues such as tooth loss. Psoriatic arthritis (PsA) is an autoimmune condition. It causes joint pain, swelling, and stiffness. PsA causes inflammation that attacks healthy joints and tissue, leading to painful symptoms. […]

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prednisolone (Orapred, Pediapred)

What is prednisolone, and how does it work (mechanism of action)? Prednisolone is a synthetic adrenal corticosteroid (cortisone). Corticosteroids are natural substances produced by the adrenal glands located adjacent to the kidneys. Corticosteroids have potent anti-inflammatory properties, and are used in a wide variety of inflammatory conditions such as arthritis, colitis, asthma, bronchitis, certain skin […]

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diclofenac and misoprostol (Arthrotec)

What is diclofenac and misoprostol, and how does it work (mechanism of action)? Arthrotec is a combination of diclofenac and misoprostol. Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) similar to ibuprofen (Motrin or Advil), naproxen (Naprosyn), and others that is used to treat inflammation, pain, and fever. Diclofenac, like other NSAIDs works by inhibiting the […]

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How can psoriatic arthritis affect the feet?

How can psoriatic arthritis affect the feet?

Psoriatic arthritis can cause substantial pain and swelling in the feet and toes. Feet-related symptoms are a common cause of decreased mobility in people with the condition. Psoriatic arthritis (PsA) is a chronic condition that causes pain, swelling, and inflammation in the joints. It also causes dactylis, which is the swelling of entire toes or […]

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Pigmented Villonodular Synovitis (PVNS)

Pigmented villonodular synovitis (PVNS) facts* *Pigmented villonodular synovitis (PVNS) facts written by Charles P. Davis, MD, PhD Pigmented villonodular synovitis (PVNS) is a disease where the tissue lining the joints and tendons grow abnormally to produce a noncancerous mass or tumor. There are two types: local (nodular) and diffuse. Local involves one area of the […]

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leflunomide (Arava)

What is leflunomide, and how does it work (mechanism of action)? Leflunomide is an oral, disease-modifying drug that is used in the treatment of rheumatoid arthritis. Leflunomide reduces inflammation in the joints that is responsible for both the symptoms of rheumatoid arthritis and the destruction of joints. This reduces symptoms as well as the progressive […]