What is dutaseride? How does it work (mechanism of action)?

Dutasteride is a medication used for the treatment of benign prostatic hyperplasia (BPH) also known as an enlarged prostate. Dutasteride belongs to a class of medication called 5-alpa reductase inhibitors. Male hormone dihydrotestosterone (DHT) is primarily responsible for development and enlargement of the prostate gland. Testosterone is converted into DHT by 5-alpha reductase enzyme. Dutasteride blocks 5-alpha reductase enzyme and prevents excessive DHT production in the prostate gland. This delays the progression of an enlarged prostate and improves symptoms of BPH.

The FDA approved dutasteride in November 2001.

What are the uses for dutasteride?

Dutasteride is used for the treatment of benign prostatic hyperplasia. It improves symptoms of enlarged prostate, reduces retaining of urine, and reduces the risk of the need for prostate surgery.

What are the side effects of dutasteride?

Dutasteride causes many sexual side effects.

Common side effects are:

Allergic reaction such as swelling under the skin may occur. Dutasteride also increases risk of high-grade prostate cancer. Patients must contact their healthcare professional if unusual reactions to dutasteride occur.

What is the dosage for dutasteride?

The recommended dose of dutasteride is 0.5 mg once daily. Do not chew the medication and do not administer to pediatric patients.

Is dutasteride safe to take if I’m pregnant or breastfeeding?

Dutasteride is not recommended to pregnant females because it can cause birth defects in the unborn child.

It is not known whether dutasteride enters breast milk.

What else should I know about dutasteride?

What preparations of dutasteride are available?

Dutasteride is available as 0.5 mg liquid-filled capsules.

How should I keep dutasteride stored?

Dutasteride capsules should be stored between 15 C to 30 C (59 F to 86 F).

Dutasteride is available in generic form, but must be prescribed by a doctor or other health-care professional. The brand name available for dutaseride is Avodart.

Medically Reviewed on 3/14/2019

References

Medically reviewed by John P. Cunha, DO, FACOEP; Board Certified Emergency Medicine

REFERENCE:

FDA Prescribing Information.